Drug-induced corneal disorders
This type of cataract often requires surgery even in the earliest stages. The macular toxicity of tamoxifen may also predispose to macular hole formation.
This can occur at any time that the medication is being used. The mechanism of action is poorly understood PDR The rise in pressure can be very high but if often asymptomatic.
Given the dose-effect relationship demonstrated recently and the potential for edema resolution after discontinuation of the drug, it is important to consider amantadine as a cause of corneal edema in all patients taking this medication.
Corneal melting and perforation in Stevens Johnson syndrome following topical bromfenac use. Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery. Control of tachyarrhythmias associated with Wolff-Parkinson-White syndrome by amiodarone hydrochloride.
The Differential Diagnosis Causes of corneal edema include endothelial disorders, inflammatory processes, ocular surgery, trauma and toxins. Glaucoma medications can also cause corneal disorders, such as keratitis punctata beta-blockersoedema carbonic anhydrase inhibitors or recurrent herpes simplex keratitis prostaglandin analogues.
Chlorpromazine-induced corneal toxicity. Eye complications caused by chloroquine in patients with rheumatoid arthritis.
Retinal findings of toxicity include speckled pigmentation and narrowed arterioles typical of damage to the retinal pigment epithelium and photoreceptors. It can develop rapidly, with the vision often declining in a matter of weeks to months.
This is reversible if the medication is stopped.
The educational update stated: There is often in package inserts with theses medications that the drug should not be used if one has glaucoma. Amiodarone Medications Discussed Include: The retina does need a normal amount of vitamin A to properly function, and this amount can be obtained with a well balanced diet without supplements. Reversible amantadine-induced corneal edema in an adolescent.
The effects of the topical administration of non-steroidal anti-inflammatory drugs on corneal epithelium and corneal sensitivity in normal subjects.
Other ocular side-effects include cataracts, retrobulbar optic neuritis, pigmentary retinopathy, bull's eye maculopathy and vitelliform maculopathy. These study types are subject to impotence erectile dysfunction synonym kinds of bias.
Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug. Cataract is also possible.
It generally begins during the fifth decade of life and gradually progresses. A less common endothelial dystrophy is posterior polymorphous corneal dystrophy, a disease affecting younger patients. Visual functions and adverse ocular effects in patients with amiodarone medication.
Thompson Healthcare, Montvale, NJ; Corneal changes during chloroquine treatment. Cancer ; With longer term use, a pigmentary retinal degeneration can also occur when can lead to visual loss.
Persisiting corneal erosion under cetuximab Erbitux treatment epidermal growth factor receptor antibody. Corneal sensitivity and burning sensation.
Although no changes consistent with Fuchs' endothelial dystrophy or other endothelial dystrophies were present in the peripheral cornea, the possibility of these conditions was entertained, along with the possibility of amantadine toxicity. Topamax Medications Discussed Include: Eye ; What's Your Diagnosis?
The eye in systemic inflammatory diseases. Pigmentation of various body sites including skin, nails, bone, mouth and eyes secondary to minocycline therapy has been reviewed recently. Ophthalmology ; Tetracyclines Medications Discussed Include: Interventional case series.
Amantadine and corneal deposits. Severe corneal complications associated with topical indomethacin use.
These sections are not intended to replace the professional examination and diagnosis by a physician, and they are presented here purely for informational purposes. Comments This article is from January and may contain outdated material.
They found that the group taking amantadine had lower endothelial cell counts and lower hexagonality of endothelial cells. Amiodarone Cordarone, Pacerone Amiodarone is an antiarrhythmic medication used to treat serious cardiac arrhythmias such ventricular tachycardia or ventricular fibrillation as well as some atrial arrhythmias.
An ocular syndrome has been identified characterized by acute myopia and secondary angle closure glaucoma.
While the exact mechanism of endothelial damage from amantadine is unknown, it appears to be a well-documented side effect that is easily overlooked in the differential of corneal edema. Sincethere have been a number of case reports of endothelial damage associated with amantadine Chang et al.
Corneal complications associated with topical ophthalmic use of nonsteroidal antiinflammatory drugs. Jpn J Ophthalmol ; Isotretinoin Accutane is no longer available Medications Discussed Include: Corneal edema is a widespread phenomenon following cataract surgery: